Scientific Studies

USF Studies:

Dr. Dominic D'Agostino

A Deep Dive Into Ketosis: How Navy Seals, Extreme Athletes & Busy Executives Can Enhance Physical and Mental Performance With The Secret Weapon of Ketone Fuel. Improve oxygen efficiency…Acetoacetate having anti-seizure effect-Check between 00:32:32 and 00:33:16

Cancer Treatment -Ketogenic Diet

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

Breaking News! Nontoxic cancer therapy proves effective against metastatic cancer

From Dr. D’Agostino at USF: ” Oncologists use FDG-PET for tumor imaging, but they don’t use this information to kill the tumor. FDG-PET is possible because cancer cells have high glucose metabolism and elevated rates of glycolysis. Mitochondrial dysfunction forces cancer cells to rely on glucose for survival (Warburg effect). Impaired mitochondrial function makes cancer cells selectively vulnerable to metabolic therapies that lower blood glucose and elevate blood ketones, a fuel that cancer cells can’t use. In fact, evidence exists that ketones are toxic to cancer cells. ”

The ketone metabolite β -hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

Metabolic therapy: A new paradigm for managing malignant brain cancer.

Cancer as a Metabolic Disease

Dr. Thomas Seyfried, Professor Biology
Thomas Seyfried

Impaired Mitochondrial Function and Tumorigenesis video below

Warburg Rules! A Review of Thomas Seyfried’s Cancer As a Metabolic Disease- From the Townsend Letter December 2012

"He cites research showing that if you transplant a nucleus containing mutations from a cancer cell into a normal cell (from which the nucleus has been removed), this does not produce cancer cells (McKinnell 1969; Mintz 1975; Howell 1978; Harris 1988; Shay 1988; Li 2003; Hochedlinger 2004). But if you transplant a normal nucleus into a cancerous cell, the cell can now form tumors – again, presuming that the original nuclear material has been removed (Israel 1987; Israel 1988). These results show that nuclear gene mutations alone cannot produce tumors and that normal mitochondria can suppress tumor formation."
nuclearcytoplasmic transfer experiments

Brain cancer (and most forms of cancer) a metabolic disease with metabolic solutions

Ketogenic diet beats chemotherapy for almost all cancers

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

Cancer as a Metabolic Disease: Implications for Novel Therapeutics

Targeting energy metabolism in brain cancer: review and hypothesis

Other studies

Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. “Ketosis, but not calorie deficit or weight loss, correlated with stable disease or partial remission.”

Hormonal regulation of ketone-body metabolism in man.

Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects

Oestrogen Reduces Aggression In Breast Cancer

Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells

Vitamin A produces astonishing leukemia cure rate, even without chemotherapy

Coley’s Toxins: A Cancer Treatment History

Tumor Cells Engineer Acidity to Drive Cell Invasion, Moffitt Cancer Center Researchers Say

Anti-diabetic effect of alkaline-reduced water on OLETF rats.

Middle and Long-Term Impact of a Very Low-Carbohydrate Ketogenic Diet on Cardiometabolic Factors: A Multi-Center, Cross-Sectional, Clinical Study

Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model

Could Metabolic Therapy Become a Viable Alternative to the Standard of Care for Managing Glioblastoma?

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy

Ketone esters for treatment of angelman syndrome


Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153)

Glutamine blocks lipolysis and ketogenesis of fasting.

Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site.

The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model

Diets higher in animal and plant protein are associated with lower adiposity and do not impair kidney function in US adults.

Acetoacetate accelerates muscle regeneration and ameliorates muscular dystrophy in mice

Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia

Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts.

Successful Treatment of Severe Cardiomyopathy in Glycogen Storage Disease Type III With D,L-3-Hydroxybutyrate, Ketogenic and High-Protein Diet

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